Light Transmission Aggregometry
in platelet rich plasma
LTA is considered to be the ‘gold standard’ for in vitro platelet function testing and is usually expected by regulatory authorities if any platelet testing is required in a drug development programme. We have extensive experience in assessing platelet aggregation by LTA and will design a study protocol that is specific and sensitive to assess the effects of your candidate compound on platelet function.
This technique is based on measuring the light transmitted through a sample of platelet rich plasma (PRP), placed between a light source and a photocell. The platelet suspension allows relatively little light to pass through. The addition of an agonist causes platelet aggregation so the sample becomes clearer and more light is transmitted to the detector; readings are recorded as a function of time.
Get in touch with the team today to find out how we can help you with platelet function testing.
Manolopoulos P. et al (2008)
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